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UNC2881

Product Name
UNC2881
CAS No.
1493764-08-1
Chemical Name
UNC2881
Synonyms
110849;UNC2881;CS-1177;UNC2881 USP/EP/BP;UNC 2881; UNC-2881;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide;2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
CBNumber
CB52715677
Molecular Formula
C25H33N7O2
Formula Weight
463.58
MOL File
1493764-08-1.mol
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UNC2881 Property

Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form 
solid
pka
12.70±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
50mg
Price
$775
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
10mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
25mg
Price
$414
Updated
2024/03/01
Tocris
Product number
6537
Product name
UNC2881
Purity
≥98%(HPLC)
Packaging
5
Price
$89
Updated
2021/12/16
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UNC2881 Chemical Properties,Usage,Production

Description

UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

Uses

UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.

target

Mer tyrosine kinase

storage

Store at +4°C

References

[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.

UNC2881 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2881 Suppliers

China 52 India 2 United Kingdom 2 United States 11 Global 67
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58

1493764-08-1, UNC2881Related Search:

UNC2541 UNC 1999 UNC0379 UNC 1025 UNC2250 GSK2656157 GSK 2334470 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Afatinib AZD-9291 UNC 669 UNC0321 UNC-1215 UNC-926 Hydochloride UNC3230 UNC0646 UNC2025 UNC 1079

  • 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
  • UNC2881
  • N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
  • N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881
  • N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine
  • 110849
  • UNC 2881; UNC-2881
  • CS-1177
  • 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
  • UNC2881 USP/EP/BP
  • N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide
  • UNC 2881,Mer,phosphorylation,inhibit,UNC-2881,orally active,UNC2881,Tyro3,pathologic thrombosis,Axl,Inhibitor,platelet aggregation,TAM Receptor
  • 1493764-08-1
  • Inhibitors